Evanescent-wave cavity ring-down spectroscopy for enhanced detection of surface binding under flow injection analysis conditions

摘要

The feasibility of liquid-phase evanescent-wave cavity ring-down spectroscopy (EW-CRDS) for surface-binding studies under flow-injection analysis (FIA) conditions is demonstrated. The EW-CRDS setup consists of an anti-reflection coated Dove prism inside a linear cavity (with standard or super-polishing of the total internal reflective (TIR) surface). A teflon spacer with an elliptical hole clamped on this surface acts as a 20 uL sized flow cell. The baseline noise of this system is of the order of 10